SyrSpend® SF is a GMP-produced oral liquid vehicle that is supported by extensive scientific literature. In a study published in the April edition of Die Pharmazie, the physical and chemical stability of 10 APIs (Active Pharmaceutical Ingredients) was studied in SyrSpend® SF PH4 liquid1:
- Imipramine hydrochloride
- Minocycline hydrochloride
- Tacrolimus monohydrate
- Tramadol hydrochloride
The beyond-use date for almost all studied SyrSpend® SF suspensions is 90 days stored under refrigerated conditions (2-8°C) and at room temperature (20-25°C). Minocycline hydrochloride has a beyond-use date of 60 days at both storage temperatures, levodopa/carbidopa and lorazepam have respectively 30 and 60 days stability at room temperature.
An overview of all available formulations with SyrSpend® SF can be found on our free online formulations database, Compounding Matters.
1Polonini HC, Silva SL, Cunha CN, Brandão MAF, Ferreira AO. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend® SF PH4 oral suspensions. Die Pharmazie, 71: 185-191 (April 2016).