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SyrSpend™ SF is an innovative vehicle range for preparing oral liquid dosage forms. The excellent compatibility with a broad range of medications and meticulous ingredient safety make SyrSpend™ SF vital for every compounding pharmacist.
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SyrSpend® SF – Scientific evidence for another 10 APIs

Thu, 14/04/2016

SyrSpend® SF is a GMP-produced oral liquid vehicle that is supported by extensive scientific literature. In a study published in the April edition of Die Pharmazie, the physical and chemical stability of 10 APIs (Active Pharmaceutical Ingredients) was studied in SyrSpend® SF PH4 liquid1:

  • Cholecalciferol
  • Haloperidol
  • Imipramine hydrochloride
  • Levodopa/carbidopa
  • Lorazepam
  • Minocycline hydrochloride
  • Tacrolimus monohydrate
  • Terbinafine
  • Tramadol hydrochloride
  • Valsartan

The beyond-use date for almost all studied SyrSpend® SF suspensions is 90 days stored under refrigerated conditions (2-8°C) and at room temperature (20-25°C). Minocycline hydrochloride has a beyond-use date of 60 days at both storage temperatures, levodopa/carbidopa and lorazepam have respectively 30 and 60 days stability at room temperature.

An overview of all available formulations with SyrSpend® SF can be found on our free online formulations database, Compounding Matters.

1Polonini HC, Silva SL, Cunha CN, Brandão MAF, Ferreira AO. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend® SF PH4 oral suspensions. Die Pharmazie, 71: 185-191 (April 2016).