Fagron Concepts

Fagron Advanced Derma is the revolutionary global standard for advanced skin care. It offers pharmaceutical bases that are formulated according to the latest scientific knowledge
Looking at expanding or starting up compounding in your pharmacy? Fagron can assist you in furnishing your lab in compliance with the Pharmacy Board Compounding Guidelines
SyrSpend® SF is an innovative vehicle range for preparing oral liquid dosage forms. The excellent compatibility with a broad range of medications and meticulous ingredient safety make SyrSpend® SF vital for every compounding pharmacist.

Pentravan® and Pentravan® Plus

Thu, 08/09/2016

Pentravan® is an oil-in-water emulsion base that uses liposomal technology to ensure effective and proven transdermal drug delivery (1-5). Pentravan® is a fragrance-free vanishing cream, providing an elegant skin feel. An in vitro absorption study with different APIs shows that Pentravan® delivers more drug in a shorter amount of time than PLO.

Pentravan® Plus is a higher viscosity version of Pentravan®; it uses the same liposomal technology as Pentravan®, but with additional emulsifiers to allow for incorporation of higher concentrations (>25%) of APIs and solvents. Pentravan® Plus vanishes into the skin, enhancing penetration of the APIs without leaving a sticky residue on the skin. 

Benefits of Pentravan® and Pentravan® Plus:

  • Ready-to-use
  • Elegant skin feel
  • Non-greasy, vanishes quickly
  • Fragrance-free

1 Lehman PA, Raney SG. In vitro percutaneous absorption of ketoprofen and testosterone: comparison of pluronic lecithin organogel vs. pentravan cream. Int J Pharm Compd. 2012;16(3):248-52. 
2 H. Maia Jr.1,2, C. Haddad2, R. Maia2 et al. Pulsatile administration of testosterone by the vaginal route using Pentravan®. Monduzzi Editoriale. 2013;181-184. 
3 Polonini HC, de Bastos CA, de Oliveira MA et al. In vitro drug release and ex vivo percutaneous absorption of resveratrol cream using HPLC with zirconized silica stationary phase. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;947-948:23-31. 
4 Hudson CP, Pedro PSm Marcone ALO et al. Transdermal formulations containing human sexual steroids: development and validation of methods and in vitro drug release. Quím. Nova. 2014;37(4):720-728. 
5 Polonini HC, Brandão MAF, Ferreira AO et al. Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream. IJPC 2014; 18(4):332-340.