Pentravan® is an oil-in-water emulsion base that uses liposomal technology to ensure effective and proven transdermal drug delivery (1-5). Pentravan® is a fragrance-free vanishing cream, providing an elegant skin feel. An in vitro absorption study with different APIs shows that Pentravan® delivers more drug in a shorter amount of time than PLO.
Pentravan® Plus is a higher viscosity version of Pentravan®; it uses the same liposomal technology as Pentravan®, but with additional emulsifiers to allow for incorporation of higher concentrations (>25%) of APIs and solvents. Pentravan® Plus vanishes into the skin, enhancing penetration of the APIs without leaving a sticky residue on the skin.
Benefits of Pentravan® and Pentravan® Plus:
- Elegant skin feel
- Non-greasy, vanishes quickly
1 Lehman PA, Raney SG. In vitro percutaneous absorption of ketoprofen and testosterone: comparison of pluronic lecithin organogel vs. pentravan cream. Int J Pharm Compd. 2012;16(3):248-52.
2 H. Maia Jr.1,2, C. Haddad2, R. Maia2 et al. Pulsatile administration of testosterone by the vaginal route using Pentravan®. Monduzzi Editoriale. 2013;181-184.
3 Polonini HC, de Bastos CA, de Oliveira MA et al. In vitro drug release and ex vivo percutaneous absorption of resveratrol cream using HPLC with zirconized silica stationary phase. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;947-948:23-31.
4 Hudson CP, Pedro PSm Marcone ALO et al. Transdermal formulations containing human sexual steroids: development and validation of methods and in vitro drug release. Quím. Nova. 2014;37(4):720-728.
5 Polonini HC, Brandão MAF, Ferreira AO et al. Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream. IJPC 2014; 18(4):332-340.