Fagron Concepts

Fagron Advanced Derma is the revolutionary global standard for advanced skin care. It offers pharmaceutical bases that are formulated according to the latest scientific knowledge
Looking at expanding or starting up compounding in your pharmacy? Fagron can assist you in furnishing your lab in compliance with the Pharmacy Board Compounding Guidelines
SyrSpend® SF is an innovative vehicle range for preparing oral liquid dosage forms. The excellent compatibility with a broad range of medications and meticulous ingredient safety make SyrSpend® SF vital for every compounding pharmacist.

Expanding SyrSpend® SF’s scientific stability database

Fri, 27/11/2015

SyrSpend® SF is Fagron’s innovative vehicle range for compounding oral liquid dosage forms. Its unique starch-based active suspending technology provides a low viscosity when shaken to ease rehomogenization, and a high viscosity at rest to keep APIs safely suspended. This ensures high dosing accuracy and consistency throughout treatment.

The use of starch also means that SyrSpend® SF is virtually chemically inert and therefore compatible with a broad range of APIs. To demonstrate this wide compatibility, Fagron has started to study the physical-chemical stability of more than 100 commonly used active pharmaceutical ingredients (APIs) in SyrSpend® SF. The API concentration for each study has been selected to allow for easy dosing for children and/or adults, based on an extensive review of commonly prescribed concentrations, scientific literature and (inter)national formularies. The results of these studies will be published in a series of international, peer-reviewed, scientific articles.

A new article has recently been published in the high-impact Journal of Pharmaceutical and Biomedical Analysis.This article discusses the stability of the following 10 drugs, from a variety of pharmacological classes, in SyrSpend® SF:

  • Amlodipine besylate
  • Chloroquine phosphate
  • Dapsone
  • Phenytoin
  • Pyridoxine hydrochloride
  • Sulfadiazine
  • Sulfasalazine
  • Tetracycline hydrochloride
  • Trimethoprim
  • Zonisamide

An overview of all available formulations with SyrSpend® SF can be found on our free online Compounding Matters formulations database.